This should count, but all the hacking/puzzle parts in the original Bioshock.
I try to avoid puzzles as much as possible and it completely interferes the game-flow of that game, to go from first person shooting/survival to a machine hacking game.
Before I knew I wanted to play Bioshock Infinite, I thought I might want to play the other games first, but the puzzle hacking of 1 destroyed that idea. I wasn't very good at the tight corridors, nor did I really like the setting of Rapture at all, anyway.
Infinite was a rare example of a FPS I like, as most I generally do not.
But yeah, the puzzle hacking game in Bioshock 1 killed the game for me way earlier than it would've normally.