I saw this one on YouTube and did it. Wonderlocke: Every Pokemon you get you must nickaname and wondertrade, other than that it’s your normal nuzlocke. I also put in an extra rule that once I beat a gym leader all the pokémon I used for that gym, my team, were dead and I had to switch.

Note: Spiritlocke rules indicate you can't catch ghosts.

Being serious for a second, I'll give out an actual idea rather then just using Weedle as an excuse for a joke. Rottinglocke: All of your pokemon has to be poisoned unless it's a Poison type. And the chances of finding poison type pokemon in the wild are reduced unless you evolve or something.

Routelocke: can only use a pokemon for the route it is on and the adjacent ones. If there is a town adjacent to the route then you can use it in the town.

Velvetlocke: The nuzlocke rules may need to be slightly more lenient in this case in terms of catching rules. In this run, you can trade a certain amount and/or type of pokemon for a new pokemon, with fusion mistake chances and all, and depending on the gym badges you collected (as a replacement for arcanas) and the type of pokemon it is, it can have a higher level.

I don't have a pokemon game or a DS/3DS but I do have an idea for a locke: Angellocke: A randomizer shiny egglocke with no "death", but the only way you can "revive" a pokemon is by keeping it in the box and healing it in the next town. You can also have no "catch the pokemon in a certain area" rules, just no nuzlocke rules and such. And you can also not have to trade pokemon and such and yeah.

A thing I heard of somewhere, slightly adapted: N-Locke: Same rules as a regular Nuzlocke, but unlike a regular one, you must release your current team (starters are an exception) after each badge.

How about a typelock. Where for the whole game, you can only use and catch one type of Pokemon, fire, water etc. Even when giggling for weakness you could win if you have a move they are weak to. It's not hard but fun.