Since this thread is alive anyway.
I did my NG+ playthrough on safe since I wanted to get some trophies.
On safe you can beat the reaper on one of your first few trips to mementos since it lets you fully revive for free. It takes a while though, so having a persona from your previous playthrough that can do good damage is a must.
Having level 80's going into the second palace is more entertaining than you'd think.